The Board consists of Secretaries to the following departments in ex-officio capacity; four nominated private members and Secretary, TDB as Member Secretary in ex-officio capacity:
- Prof. Abhay Karandikar, Secretary, DST & Chairman, TDB
- Dr. (Mrs.) N. Kalaiselvi, Secretary, DSIR & DG, CSIR
- Dr. Samir V Kamat, Secretary, DDR&D and Chairman DRDO
- Dr. Manoj Govil, Secretary, Department of Expenditure
- Shri Amardeep Singh Bhatia, Secretary, Department for Promotion of Industry and Internal Trade (DPIIT), Ministry of Commerce & Industry,
Government of India - Shri Shailesh Kumar Singh, Secretary, Department of Rural Development
- Dr. Debashish Bhattacharjee, Former Vice President- Technology and R&D Tata Steel
- Ms. Padmaja Ruparel, Co-Founder, Indian Angel Network (IAN)
- Mr. Shriprakash Shukla, Chairman of the Boards in Mahindra Defence Systems, Mahindra Aerostructures and Mahindra Telephonics
- Ms. Vandana Gupta, Company Secretary and Compliance Management, Mitsubishi Corporation
- Shri Rajesh Kumar Pathak, Secretary, TDB
